PACCM Education Resources

Dr. Matt Pipeling's Lung Transplant Curriculum

1. Transplant Overview

• Hardy JD, Webb WR, Dalton ML Jr, Walker GR Jr. Lung Homotransplantation in Man. JAMA. 1963;186:1065–1074. doi:10.1001/jama.1963.63710120001010


• ATS. Lung Txp MiniSeries #1 - What is Lung Transplantation? 2015.


• Kotloff RM, Thabut G. Lung transplantation. Am J Respir Crit Care Med. 2011;184(2):159–171. doi:10.1164/rccm.201101-0134CI


• ISHLT. Lung Transplantation - Adult Patients. 2016. (ppt) (PDF)

2. Candidate Referral and Selection

• ATS. Lung Txp MiniSeries #2 - Recipient Selection for Lung Transplantation. 2016.


• Weill D, Benden C, Corris PA, et al. A consensus document for the selection of lung transplant candidates: 2014--an update from the Pulmonary Transplantation Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2015;34(1):1–15. doi:10.1016/j.healun.2014.06.014


• Kreider M, Kotloff RM. Selection of candidates for lung transplantation. Proc Am Thorac Soc. 2009;6(1):20–27. doi:10.1513/pats.200808-097GO

3. Acute Rejection

• Martinu T, Chen DF, Palmer SM. Acute rejection and humoral sensitization in lung transplant recipients. Proc Am Thorac Soc. 2009;6(1):54–65. doi:10.1513/pats.200808-080GO


• Stewart S, Fishbein MC, Snell GI, et al. Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection. J Heart Lung Transplant. 2007;26(12):1229–1242. doi:10.1016/j.healun.2007.10.017

4. Chronic Rejection

• Estenne M, Maurer JR, Boehler A, et al. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant. 2002;21(3):297–310. doi:10.1016/s1053-2498(02)00398-4


• Weigt SS, DerHovanessian A, Wallace WD, Lynch JP 3rd, Belperio JA. Bronchiolitis obliterans syndrome: the Achilles' heel of lung transplantation. Semin Respir Crit Care Med. 2013;34(3):336–351. doi:10.1055/s-0033-1348467


• Belperio JA, Weigt SS, Fishbein MC, Lynch JP 3rd. Chronic lung allograft rejection: mechanisms and therapy. Proc Am Thorac Soc. 2009;6(1):108–121. doi:10.1513/pats.200807-073GO


• Vos R, Verleden SE, Verleden GM. Chronic lung allograft dysfunction: evolving practice. Curr Opin Organ Transplant. 2015;20(5):483–491. doi:10.1097/MOT.0000000000000236


• Verleden GM, Raghu G, Meyer KC, Glanville AR, Corris P. A new classification system for chronic lung allograft dysfunction. J Heart Lung Transplant. 2014;33(2):127–133. doi:10.1016/j.healun.2013.10.022


• Sato M, Waddell TK, Wagnetz U, et al. Restrictive allograft syndrome (RAS): a novel form of chronic lung allograft dysfunction. J Heart Lung Transplant. 2011;30(7):735–742. doi:10.1016/j.healun.2011.01.712


• Finlen Copeland CA, Snyder LD, Zaas DW, Turbyfill WJ, Davis WA, Palmer SM. Survival after bronchiolitis obliterans syndrome among bilateral lung transplant recipients. Am J Respir Crit Care Med. 2010;182(6):784–789. doi:10.1164/rccm.201002-0211OC

5. Immunosuppression

• Scheffert JL, Raza K. Immunosuppression in lung transplantation. J Thorac Dis. 2014;6(8):1039–1053. doi:10.3978/j.issn.2072-1439.2014.04.23


• Treede H, Glanville AR, Klepetko W, et al. Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: results of a prospective, randomized international trial in lung transplantation. J Heart Lung Transplant. 2012;31(8):797–804. doi:10.1016/j.healun.2012.03.008


• Watkins KD, Boettger RF, Hanger KM, et al. Use of sublingual tacrolimus in lung transplant recipients. J Heart Lung Transplant. 2012;31(2):127–132. doi:10.1016/j.healun.2011.10.015


• Knoop C, Haverich A, Fischer S. Immunosuppressive therapy after human lung transplantation. Eur Respir J. 2004;23(1):159–171. doi:10.1183/09031936.03.00039203